活检证明的脂肪性肝病和脂肪性肝炎中的循环激素:一个多中心观察性研究
Laura Valenzuela-Vallejo1, Pavlina Chrysafi1, Matina Kouvari1
1Department of Medicine, Beth-Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, United States of America.
Metabolism: clinical and experimental
|September 27, 2023
概括
增长分化因子-15 (GDF-15) 和其他激素在与代谢功能障碍相关的脂肪性肝病 (MASLD) 中发生变化. 这些荷尔蒙变化与MASLD的严重程度相关,可能有助于诊断和治疗.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
背景情况:
- 代谢和炎症激素系统在代谢功能障碍相关的脂肪性肝病 (MASLD) 中的作用需要进一步阐明.
- 了解这些荷尔蒙通路对于解决MASLD日益增长的流行和影响至关重要.
研究的目的:
- 量化生长分化因子-15 (GDF-15) 和其他激素在MASLD患者和对照者的水平.
- 确定与MASLD及其不同阶段相关的荷尔蒙模式,包括纤维化严重程度.
主要方法:
- 一项涉及455个血清样本的多中心研究,这些血清样本来自活检证明的MASLD患者 (n=374) 和健康对照者 (n=81).
- 分析包括测量了总和H特异性的GDF-15,folistatin-like-3 (FSTL-3),自由胰岛素类生长因子-1 (IGF-1),莱普,胰岛素,阿迪波内克丁,活性蛋白-A和folistatin (FST).
主要成果:
- 与对照组相比,MASLD患者的总和H特定GDF-15,FSTL-3,IGF-1,瘦素和胰岛素水平显著更高.
- 在MASLD患者中,阿迪波涅丁水平较低. 荷尔蒙水平,包括GDF-15和胰岛素,随着纤维化的严重程度而增加.
- 确定了两种与风险代谢功能障碍相关的脂肪肝炎 (MASH) 相关的两种不同的荷尔蒙模式,表明不同的病理生理路径.
结论:
- 激素系统,特别是GDF-15,在MASLD及其进展中发生显著变化.
- 这些荷尔蒙标志物可以作为诊断和MASLD的分期有价值的工具.
- 对这些荷尔蒙通路的进一步研究可能会揭示MASLD的潜在治疗点.
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