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富含纤维的饮食减轻了小鼠的化疗相关的神经炎症

Courtney Cross¹, Maya Davies¹, Emma Bateman¹

¹School of Biomedicine, University of Adelaide, South Australia, Australia; Supportive Oncology Research Group, Precision Cancer Medicine (Theme), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide, South Australia, Australia.

Brain, behavior, and immunity

|September 27, 2023

概括

富含纤维的饮食通过改变肠道微生物群和增加短链脂肪酸 (SCFA) 来减少化疗引起的神经炎症. 这突出了肠-大脑轴作为缓解化疗的目标.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

肠道微生物群通过短链脂肪酸 (SCFA) 影响神经系统状况.
化疗,如5-甲 (5-FU),引起神经炎症,影响认知,情绪和能量水平.
针对化疗诱导的神经炎症的基于微生物的治疗方法仍未得到充分研究.

研究的目的:

为了研究高纤维饮食对5-FU诱导的神经炎症的影响.
探索如何饮食纤维调节肠道微生物群及其代谢物在化疗的背景下.
评估肠道微生物变化与神经炎症标志物之间的关系.

主要方法:

小鼠接受了5-FU或车载,有或没有高纤维饮食.
用16S rRNA基因测序分析了肠道微生物组成.
短链脂肪酸 (SCFA) 度通过气色谱质谱法 (GC-MS) 来测量.
通过量化海马体和中脑中的星球细胞密度 (GFAP) 来评估神经炎症.

主要成果:

高纤维饮食显著改变了肠道微生物群,增加了Bacteroidaceae和Akkermansiaceae.
在食用高纤维饮食的小鼠中, propionate 产量增加.
食纤维降低了接受5FU治疗的小鼠海马和中脑中的天体细胞密度.
星细胞密度与酸盐水平和特定细菌丰度有负相关性.

结论:

食纤维摄入量可以减轻化疗诱导的神经炎症.
肠道微生物群-大脑轴是减少化疗的神经毒性影响的潜在治疗点.
富含纤维的饮食有望缓解化疗相关的神经免疫变化.

关键词:

化学大脑是什么意思化疗化疗是一种化学疗法.饮食饮食饮食饮食纤维纤维是一种纤维.肠-大脑轴肠-大脑轴微生物组是一个微生物组.微生物群中的微生物群

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