德鲁森和其他视网膜发现在患有IgA球体膜炎的人
Ursula Greferath1, Erica Fletcher1, Judy Savige1
1University of Melbourne, Parkville, Victoria, Australia (U.G., E.F., J.S., H.G.M.).
American journal of ophthalmology
|September 27, 2023
概括
在IgA脏病中,即使是患有功能衰竭,视网膜干燥不常见. 这些德鲁森类似于与年龄相关的黄斑退行症中发现的,这表明值得进一步研究的潜在联系.
科学领域:
- 眼科医生 眼科 眼科
- 腎臟病學 (nephrology) 是一種醫學.
- 免疫学 免疫学 免疫学
背景情况:
- 在患有IgA脏病的个体中观察到视网膜干燥.
- 需要进一步澄清IgA脏病和视网膜干燥之间的关系.
研究的目的:
- 为了确定在IgA脏病中视网膜干燥的频率.
- 为了比较IgA脏病中的德鲁森的位置和组成与与年龄相关的黄斑变性.
主要方法:
- 一个免疫组织学案例系列在IgA脏病患者的捐赠者眼睛上进行.
- 使用特定抗体分析了德鲁森的存在,位置和组成.
- 结果与在与年龄相关的黄斑变性中发现的drusen进行了比较.
主要成果:
- 在所有IgA脏病捐赠者的皮下色素上皮质中发现了稀疏的,具有维特龙菌素阳性的毒素.
- 在视网膜毛细血管和胆管毛细血管中存在IgA染色,并且在最年轻的捐赠者中罕见的外部核层沉积物中存在.
- 最古老的捐赠者在各种视网膜层中表现出类似囊的空间,没有IgA或补充染色.
结论:
- 在IgA脏病中,视网膜干燥很少发生,即使在功能衰竭的情况下也是如此.
- 德鲁森在IgA脏病中与与与年龄相关的黄斑退行症中看到的相似之处.
- 在外核层的IgA沉积表明系统性IgA沉积和补充激活;建议进一步研究质膜炎视网膜.
更多相关视频
08:32Culturing of Retinal Pigment Epithelial Cells on an Ex Vivo Model of Aged Human Bruch's Membrane
Published on: April 12, 2018
10.3K
10:27Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
24.6K
相关概念视频
Renal Corpuscle
2.5K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.5K
Glaucoma: Overview
614
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
614
Nephrotic Syndrome I : Introduction
9
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
9
Nephrotic Syndrome II : Assessment and Medical Management
8
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
8
