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在自身免疫性肺膜蛋白质炎中的感染:一个大型的回顾性队列
Axelle Mabo1, Raphael Borie2, Lidwine Wemeau-Stervinou3
1Service de Pneumologie, Centre de Compétence pour les Maladies Pulmonaires Rares, Hôpital Pontchaillou, CHU Rennes, Rennes, France.
自身免疫性肺膜蛋白质症 (aPAP) 患者经常出现感染,特别是机会性感染,如心脏病. 早期检测缓慢生长的细菌对于在aPAP患者中管理这些感染至关重要.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 罕见疾病 罕见疾病
背景情况:
- 自身免疫性肺膜蛋白质症 (aPAP) 是一种罕见的疾病.
- aPAP增加了感染的风险,但缺乏全面的了解.
研究的目的:
- 在aPAP患者中描述感染和临床结果.
- 在aPAP中识别机会性感染的风险因素.
主要方法:
- 在法国和比利时对104名aPAP患者 (2008-2018) 的回顾性队列研究.
- 通过标准化问卷收集的数据:人口统计,并发症,成像,结果,微生物学.
主要成果:
- 58%的患者发生感染;22%患有机会性感染,主要是诺卡迪亚 (10例).
- 男性性别与机会性感染有关 (OR=3.88).
- 较高的抗GM-CSF抗体标位与无心脏病相关.
结论:
- aPAP患者容易患上机会性感染,尤其是心脏病.
- 对于aPAP患者,建议对洗液中缓慢生长的细菌进行系统查.
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