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运动员使用超生理剂量合成安卓类固醇的心脏结构和缩功能受损

Sabah Hammoud¹, Bart J F van den Bemt², Ayman Jaber³

¹Laboratory of Experimental and Clinical Pharmacology, Faculty of Sciences, Section 1, Lebanese University, Rafic Hariri Educational Campus, Hadat, Lebanon; Department of Pharmacy, Radboud University Medical Center, the Netherlands.

Journal of science and medicine in sport

|September 27, 2023

概括

在运动员中使用类固醇类固醇 (AAS) 与显著的心脏重塑和心脏功能降低有关. 这项研究强调了超生理AAS剂量对心血管的有害影响.

科学领域:

心脏病学心脏病学
运动医学运动医学
内分泌学在内分泌学.

背景情况:

运动员越来越多地使用超生理剂量的合成安卓类固醇 (AAS).
使用AAS的健康副作用经常被忽视.
心血管结构和功能对于运动表现和健康至关重要.

研究的目的:

共同评估类固醇类固醇 (AAS) 的超生理剂量对全球心血管结构的影响.
评估AAS对运动员功能能力的影响.
为了比较AAS用户,非用户运动员和久坐不动的人之间的心血管参数.

主要方法:

横截面研究设计. 截面研究设计.
包括92名男性:18名静坐运动员,26名非AAS运动员和48名AAS运动员.
用于评估心脏结构和功能的二维回声心脏学.

主要成果:

与对照组相比,AAS使用者表现出左心室和左心室重塑的增加 (p < 0.001).
在AAS使用者中,左心室质量/身体表面积 (p < 0.001) 和心脏重塑的流行率 (58.3%) 显著增加.
在AAS使用者中,减小了透功能 (E,E/A;p ≤ 0.003),减小了排泄分数与静止小组相比 (p = 0.020),并降低了全球纵向应变 (p < 0.001).
在AAS使用者中观察到三管反的增加 (p = 0.001).

结论:

类固醇类固醇 (AAS) 消费与全球心脏重塑有关,包括左心室和心房扩大.
AAS使用者表现出左心室缩和降低亚临床缩功能.
AAS的使用与门反和 sino-tubular 结口扩张相关.

关键词:

类固醇类雌激素类固醇 (Anabolic androgenic steroids) 是一种类固醇类固醇.运动员运动员心声回声扫描 (Echocardiography) 是一种心声回声扫描.过度缩过度缩过度缩的衍生品的衍生品

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