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[在内德克萨植入物后晚期类固醇诱导的眼睛高血压:20例病例的系列]
J Billant1, I Douma1, E Agard1
1Service d'ophtalmologie, hôpital d'instruction des Armées Desgenettes, Lyon, France.
Journal francais d'ophtalmologie
|September 27, 2023
概括
晚期类固醇诱导的眼睛高血压 (OHT) 可能发生在多次德甲植入物 (DEXi) 注射后,通常需要医疗或激光治疗. 对这些患者来说,长期监测至关重要.
科学领域:
- 眼科医生 眼科 眼科
- 玻璃眼研究研究 玻璃眼研究
- 药理疗法 药理疗法 药理疗法
背景情况:
- 类固醇诱导的眼睛高血压 (OHT) 影响了大约三分之一接受德甲植入物 (DEXi) 的患者.
- 这些病例中的很大一部分,超过20%,发生在第三次DEXi静脉内注射 (IVI) 后.
研究的目的:
- 研究多次DEXi IVI后晚期发展OHT的患者的临床特征.
- 分析这些迟反应者的眼内压 (IOP) 反应和管理策略.
主要方法:
- 一项对晚期类固醇诱导OHT (IOP ≥21mmHg经过≥4次DEXi IVI后) 患者的回顾性观察研究.
- 分析包括人口统计数据,IVI后2个月内心压力,以及需要服用青光眼药物的数量.
- IOP反应被分为低 (<+6mmHg),中度 (≤+15mmHg) 或高 (>15mmHg).
主要成果:
- 晚期类固醇诱导的OHT发生在20.8%的病例中,涉及18名患者的20只眼睛.
- 平均随访时间为3.8年,平均每名患者IVI9.5次.
- 第一个OHT峰值在6.8次IVI后平均为25.3mmHg;65%的峰值发生在第四和第六次IVI之间.
- 中度响应者 (85%) 是最常见的,以平均1.7种药物和0.75种SLT手术控制IOP,没有过手术.
结论:
- 晚发性类固醇诱导的OHT在接受多次DEXi注射的患者中大约有五分之一发生.
- 这些患者通常表现出中度IOP增加,通常可以通过药物治疗或选择性激光形造形 (SLT) 进行管理.
- 在DEXi治疗后经历晚期OHT的患者,长期IOP监测至关重要.
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