活跃癌症患者接受过透导管大动脉置换术的患者的结局
Antonin Trimaille1, Kensuke Matsushita1, Benjamin Marchandot2
1Division of Cardiovascular Medicine, Strasbourg University Hospital, Nouvel Hôpital Civil, 67091 Strasbourg, France; Inserm (French National Institute of Health and Medical Research), FMTS, Regenerative Nanomedicine, UMR 1260, 67000 Strasbourg, France.
Archives of cardiovascular diseases
|September 27, 2023
概括
接受过导管大动脉置换 (TAVR) 的活跃癌症患者的1年死亡率更高. 活跃癌症是死亡率的重要预测因素,并且与TAVR后的出血事件增加有关.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 干预心脏病学 干预心脏病学
背景情况:
- 心血管疾病和癌症是全球主要的死亡原因.
- 活跃癌症与跨导管大动脉置换术 (TAVR) 后的结果之间的相互作用尚未明确.
- 关于接受TAVR治疗的癌症患者的预后,存在相互矛盾的数据.
研究的目的:
- 评估活跃癌症对接受TAVR的患者预后的影响.
- 为了确定活跃癌症和TAVR后死亡率之间的关联.
主要方法:
- 对1,125名患有严重大动脉狭窄的患者进行TAVR的前性研究 (2010年2月 - 2019年5月).
- 患者被分为基线有或没有活跃癌症的群体.
- 主要终点是手术后1年的全因死亡率.
主要成果:
- 88名患者 (7.8%) 患有活跃的癌症,最常见的是血液,乳腺和前列腺癌.
- 活跃癌症患者的1年死亡率明显高 (27.3%对13.9%,P<0.01).
- 活跃癌症强烈预测了一年全因死亡率 (HR 2.46) 并与增加的出血事件有关.
结论:
- 活跃癌症与TAVR后1年全因死亡率的增加有关.
- 在患有活跃癌症的患者中观察到更高的长期出血事件趋势.
- 这些发现强调了在TAVR患者管理中考虑活跃癌症的重要性.
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