一个更安全的食品接触材料的愿景:公共卫生问题作为改善测试的驱动力
Jane Muncke1, Anna-Maria Andersson2, Thomas Backhaus3
1Food Packaging Forum Foundation, Zurich, Switzerland.
Environment international
|September 27, 2023
概括
目前的食品接触材料法规不充分评估化学风险. 建议对整体迁移进行改进的测试和扩大毒理学终点,包括六个疾病群 (SCOD),以更好地保护公众健康免受危险的食品接触化学物质 (FCC) 的影响.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 食品安全 食品安全
背景情况:
- 接触食品材料 (FCM) 广泛存在,但目前的法规不充分评估了与食品接触化学品 (FCC) 迁移的风险.
- 现有的安全测试侧重于单个物质和基因毒性,忽视内分泌干扰,非故意添加物质 (NIAS) 和其他慢性健康危害.
- FCM与非传染性疾病有关,强调需要改进风险评估.
研究的目的:
- 为FCM和与食品接触的物品提出加强的安全评估策略.
- 倡导对包括NIAS在内的成品的整体迁移进行测试.
- 扩大毒理学评估的范围,不仅仅是基因毒性,还包括与慢性疾病相关的多个健康终点.
主要方法:
- 将慢性健康结果分组为六个疾病集群 (SCOD),以确定机械测试终点.
- 建议通过不良结果途径 (AOP) 或有毒剂的关键特征开发与SCOD相关的体外试验.
- 建议对已成品与食品接触的产品进行测试,以确定其对SCOD的影响.
主要成果:
- 目前的FCM安全测试不足以保护公众健康免受危险的FCC和NIAS的影响.
- 由于不充分的危险评估,FCM增加了非传染性疾病的负担.
- 需要一个新的测试范式,重点关注整体迁移和多种疾病终点.
结论:
- 改进FCM安全评估需要评估整体迁移和更广泛的毒理终点.
- 对六种疾病集群 (SCOD) 的食品接触成品的测试将增强对化学物质暴露的保护.
- 这种方法将有助于预防与食品系统中危险化学品相关的慢性疾病.
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