生物粘合液晶作为眼科药物输送系统的未来使用
Martine Tarsitano1, Antonia Mancuso2, Maria Chiara Cristiano3
1Department of Health Science, University Magna Graecia of Catanzaro, Campus Universitario-Germaneto, Viale Europa, 88100, Catanzaro, Italy.
Scientific reports
|September 27, 2023
概括
利奥特罗普液晶提供了一种新的眼科药物输送系统,改善前角膜保留. 这些液晶在现场转化,增强眼科治疗的药物疗效.
科学领域:
- 材料科学 材料科学 材料科学
- 药品制造 药品制造 药品制造
- 生物医学工程 生物医学工程
背景情况:
- 眼科药物输送面临挑战,因为药物溶解性差,角膜前保留时间短.
- 现有的配方往往在有效的药物透和持续释放方面扎.
- 新型药物输送系统对于提高眼科治疗疗效至关重要.
研究的目的:
- 作为一种新的眼科药物输送系统,研究光热液晶.
- 评估角膜上液晶的 in situ 转化和稳定性.
- 评估通过该系统提供的模型药物的受控释放和安全概况.
主要方法:
- 热液晶 (状和立方相) 被配制为阿西克洛维尔作为一种模型药物.
- 在角膜表面的现场转化从片状到立方相被证明.
- 进行了粘度,药物释放动力学,ex vivo眼睛研究和组织病理学检查.
主要成果:
- 叶片状液晶在角膜上 in situ 转化为立方相.
- 立方相表现出稳定的粘度和剪切稀释行为跨温度和药物存在.
- 活体研究证实了角膜粘附,抗液,没有观察到组织损伤.
结论:
- 热液晶显示出作为一种有利的眼科药物输送系统的潜力.
- 在现场的相位过渡和稳定性提供了改善的前角膜保留和受控的药物释放.
- 这种系统显示出增强眼科药物的治疗效果的前景.
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