基底侧杏仁体神经Y系统调节过度饮用乙醇的消费
Stacey L Robinson1,2, Sophie C Bendrath1,2, Elizabeth M Yates1
1Department of Psychology & Neuroscience, The University of North Carolina, Chapel Hill, NC, 27599-3270, USA.
概括
在底侧杏仁体 (BLA) 中的神经Y (NPY) 影响男性的乙醇摄入量. 过度饮酒会降低BLA中的NPY1R表达,并且抑制BLA到mPFC的投影会降低两性中类似过度饮酒的乙醇消耗.
科学领域:
- 神经科学是一个神经科学.
- 神经生物学 神经生物学 神经生物学
- 成研究 研究成研究
背景情况:
- 神经Y (NPY) 信号调节与酒精消费有关的皮质膜路径.
- 底侧杏仁体 (BLA) 和其投射在调节寻求奖励的行为,包括乙醇摄入方面发挥着至关重要的作用.
- 了解NPY及其在BLA中的受体的特定作用对于开发有针对性的成疗法至关重要.
研究的目的:
- 调查BLA内NPY给药对过度饮酒类乙醇消费的影响.
- 为了检查重复的类似狂欢的乙醇摄入如何改变BLA中的NPY受体1 (NPY1R) 表达.
- 为了确定BLA对中部前额叶皮层 (mPFC) 的参与,NPY1R+投影在过度饮酒类乙醇摄入中.
主要方法:
- 在C57BL6J小鼠中利用了"喝酒在黑暗中" (DID) 的范式.
- 将NPY直接注入BLA,以评估其对乙醇摄入的影响.
- 使用免疫组织化学 (IHC) 来测量DID暴露后BLA中的NPY1R表达水平.
- 使用化学遗传学来选择性地抑制NPY1R+从BLA到mPFC的投射.
主要成果:
- 仅在雄性小鼠中,局部BLA NPY的剂量依赖性降低了暴饮暴食类乙醇摄入量.
- 重复的DID暴露导致雄性和雌性小鼠BLA中的NPY1R表达减少.
- 对BLA→mPFC NPY1R+神经元的化学遗传沉默显著减弱了两性中剂量依赖的过度饮酒类乙醇摄入量.
结论:
- 在BLA内使用NPY调节过度饮食类型的乙醇摄入量,在男性中观察到性别特异性影响.
- 过度饮酒类乙醇消费与BLA.内NPY1R表达的降低有关.
- 将BLA连接到mPFC的NPY1R+通路在调节两性之间类似狂饮的乙醇消费方面发挥着关键作用.
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