相关实验视频
Updated: Jul 15, 2025

09:36
Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
27.1K
在出生时体重非常低的成年人中,心脏代谢健康 - - 一项兄弟研究
Nina Kaseva1, Juho Kuula2,3, Samuel Sandboge2,4
1Finnish Institute for Health and Welfare, Helsinki, Finland. nina.kaseva@fimnet.fi.
Pediatric research
|September 27, 2023
概括
与他们的兄弟姐妹相比,出生时体重非常低 (VLBW) 的成年人面临较高的葡萄糖调节和脂肪酸代谢受损的风险. 共同的家族因素可能会解释一些心脏代谢差异.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 新生儿科学 新生儿科学
背景情况:
- 过早出生且出生时体重非常低 (VLBW) 的个体在成年后患心脏代谢健康损伤的风险较高.
- 这项研究研究了成人VLBW幸存者的葡萄糖调节和心脏代谢生物标志物,利用完全兄弟姐妹作为对照来解释共同的遗传和环境因素.
研究的目的:
- 评估和比较成年出生体重非常低的幸存者及其满期出生的兄弟姐妹之间的葡萄糖代谢和心脏代谢生物标志物.
- 为了确定潜在的家庭或环境对VLBW个体心脏代谢健康差异的影响.
主要方法:
- 74名出生时体重非常低 (VLBW) 的成年人队列与70名满期出生的同性兄弟姐妹相匹配.
- 参与者接受了2小时的75克口服葡萄糖耐受性测试和血液测试,以评估心脏代谢生物标志物,平均年龄为29.2岁.
主要成果:
- 31%的VLBW成年人和16%的兄弟姐妹符合葡萄糖调节受损的标准 (OR 2.5).
- 与兄弟姐妹相比,VLBW参与者表现出明显更高的2小时葡萄糖水平和自由脂肪酸度,即使经过对混因素进行调整.
- 两组之间在胰岛素耐药性,脂质概况或肝功能测试方面没有发现显著差异.
结论:
- 与他们的兄弟姐妹相比,出生时体重非常低的成年人表现出较差的葡萄糖调节和脂肪酸代谢.
- 观察到的心脏代谢生物标志物的差异不如之前的研究中那么明显,这表明共同的家族,遗传或环境因素发挥了作用.
- 在VLBW成年人中,葡萄糖调节障碍似乎独立于当前的体重指数,突出显示了早产的持久影响.
相关概念视频
Blood Studies for Cardiovascular System I: Cardiac Biomarkers
185
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
185
Regression Toward the Mean
6.3K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
6.3K
Inborn Errors of Metabolism
179
Phenylketonuria (PKU) is a protein metabolism disorder characterized by high blood levels of the amino acid phenylalanine. This results from a mutation in the gene responsible for phenylalanine hydroxylase, an enzyme that converts phenylalanine into tyrosine. When this enzyme is deficient, phenylalanine builds up in the blood, leading to symptoms such as vomiting, rashes, seizures, growth deficiency, and severe mental retardation. An early diagnosis and a diet restricting phenylalanine intake...
179
Obesity
523
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
523
Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K
Metabolic States of the Body: Fasting and Starvation
1.5K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
1.5K

