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Updated: Jul 15, 2025

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血小板激活的标志物用于识别晚期发作的婴儿败血症: PARENT研究协议

Daniel O'Reilly1,2,3, Claire Anne Murphy4, Carmel Maria Moore4,5

  • 1School of Biomolecular and Biomedical Science, University College Dublin, Dublin, 4, Ireland. daniel.oreilly2@ucdconnect.ie.

Pediatric research
|September 27, 2023
PubMed
概括

这项研究研究了新鲜的血液标志物,用于早期检测新生儿败血症. 识别血小板和内皮激活可以改善高风险新生儿的诊断,指导抗生素治疗决策.

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Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
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