相关实验视频
Updated: Jul 15, 2025
04:36
Noninvasive Electrocardiography in the Perinatal Mouse
Published on: June 12, 2020
6.1K
一个生物电相转换模式第一个脊椎动物的心跳
Bill Z Jia1,2,3, Yitong Qi1, J David Wong-Campos1
1Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Nature
|September 27, 2023
概括
第一个斑马鱼的心跳突然从不同的位置出现, 时间不规则. 逐渐发展的单个细胞的电特性导致强大的,协调组织规模的打击.
科学领域:
- 发育生物学
- 心血管生理学
- 生物物理
背景情况:
- 常规的心跳对于脊椎动物的生存至关重要,通常由成熟心脏的局部起器驱动.
- 在早期胚胎心脏中,心脏节律是广泛分布的,这就提出了关于组织规模活动的建立和维护的问题.
- 人们对心脏从静声转变为跳动的初始转变以及早期心跳的时空动力学了解甚少.
研究的目的:
- 在单个电事件的时间尺度上描述斑马鱼胚胎的第一个心跳
- 分析围绕初始心跳的心脏刺激性和导电性的发展.
- 了解异步单细胞发育如何导致组织规模协调的心脏活动.
主要方法:
- 使用全光学电生理学来捕捉斑马鱼胚胎中最早的心脏电活动.
- 分析了初始心跳和随后发展的空间和时间动态.
- 模拟生物电力动力学使用无变圆分叉框架的噪音结.
主要成果:
- 第一个心跳突然出现, 间隔不规则.
- 在原始心脏中观察到电活动的连贯传播.
- 个体胚胎之间和随着时间的推移而有所不同.
- 活动潜力的上升被确定为CaV1.2通道的驱动.
结论:
- 从静止到协调的跳动是一个强大的组织规模的现象.
- 这种转变源于单细胞生物电特性的逐步和异步发展.
- 这项研究提供了早期心电生理学和导电动学的详细描述.
相关概念视频
01:19Electrophysiology of Normal Cardiac Rhythm
5.6K
The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase...
5.6K
01:25Correlation between ECG and Cardiac Cycle
6.4K
The electrical signals recorded on an electrocardiogram (ECG) occur before the mechanical processes of contraction and relaxation during the cardiac cycle.
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
A cardiac action potential originates in the SA node and spreads throughout the atria and the AV node in approximately 0.03 seconds. This results in the P wave in an ECG and triggers atrial contraction. The action potential is then briefly slowed at the AV node, allowing the atria to contract and fill the ventricles with blood before...
6.4K
01:30Cardiac Action Potential
1.6K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
1.6K
01:28Disturbances in Heart Rhythm
997
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
997
01:13The Cardiac Cycle
88.7K
The heart beats rhythmically in a sequence called the cardiac cycle—a rapid coordination of contraction (systole) and relaxation (diastole).
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
The Process
Electrical signals—sent from the sinoatrial (SA) node in the right atrial wall to the atrioventricular (AV) node between the right atrium and right ventricle—cause both atria to simultaneously contract. When the signal reaches the AV node, it pauses for approximately a tenth of a second, allowing the atria to contract and...
88.7K
01:28Electrocardiogram Fundamentals
627
Introduction
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
An electrocardiogram (ECG) is a diagnostic tool for identifying cardiac conditions such as arrhythmias, conduction abnormalities, and myocardial ischemia.
Definition
An electrocardiogram (ECG) visualizes the heart's electrical activity by tracing the electrical movement associated with each heartbeat on a graph or monitor. As the heart beats, an electrical wave passes through it, correlating with the cardiac cycle events.
Parts of an ECG
An ECG utilizes electrodes on the skin...
627