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Updated: Jul 15, 2025

Single-step Purification of Macromolecular Complexes Using RNA Attached to Biotin and a Photo-cleavable Linker
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Published on: January 3, 2019

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通过三元Schlafen域核酶进行piRNA处理

Nadezda Podvalnaya1,2, Alfred W Bronkhorst1, Raffael Lichtenberger3,4

  • 1Biology of Non-coding RNA group, Institute of Molecular Biology, Mainz, Germany.

Nature
|September 27, 2023
PubMed
概括

研究人员发现了PUCH酶,这是piRNA生物发生的一个关键因素,它启动了C. elegans中PIWI相互作用的RNA前体的处理. 这一发现澄清了基因组免疫机制,并将它们与哺乳动物的免疫反应联系起来.

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