探索循环内分泌素和核 accumbens 功能连接对厌食症神经症严重程度的影响
Romina Miranda-Olivos1,2,3,4, Isabel Baenas1,2,3,4, Trevor Steward5
1Clinical Psychology Unit, Bellvitge University Hospital, L'Hospitalet de Llobregat, 08907, Barcelona, Spain.
Molecular psychiatry
|September 27, 2023
概括
神经性厌食症 (AN) 涉及到核突 (NAcc) 中大脑连接的改变. 内分泌大麻素 (eCBs) 与AN患者与健康对照者的NAcc连接有不同的相互作用,影响AN的严重程度.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 内分泌学 在内分泌学.
背景情况:
- 神经性厌食症 (AN) 是一种严重的精神疾病,伴有显著的体重减轻.
- 核聚集体 (NAcc) 和内分泌大麻素 (eCBs) 的变化可能会影响AN的严重程度和行为.
- 了解奖励回路和eCB之间的相互作用对于AN研究至关重要.
研究的目的:
- 为了研究NAcc功能连接性,循环eCBs (安纳胺[AEA]和2-阿拉基多糖醇[2-AG]) 和AN严重程度之间的关联.
- 为了比较NAcc功能连接和eCB度与AN和健康对照 (HC) 之间的个体.
- 探索NAcc功能连接在AN和HC中eCB和BMI之间关系中的调解作用.
主要方法:
- 使用fMRI在18名AN和18名HC的个体中评估NAcc功能连接性.
- 在两组中测量了循环中的AEA和2-AG度.
- 分析了NAcc连接,eCB水平和身体质量指数 (BMI) 之间的关联.
主要成果:
- 与HC相比,患有AN的个体显示NAcc-insula和NAcc-SMA功能连接性下降.
- 减少的NAcc-岛屿连接在AN组中调解了AEA-BMI协会.
- 在HC集团中,NAcc-SMA连接调解了AEA-BMI协会.
结论:
- 在AN中改变了NAcc-insula和NAcc-SMA连接,可能会破坏与奖励相关的信息的整合.
- 在AN和HC中,eCB和NAcc连接之间的明显关联表明了对体重维持的潜在临床影响.
- eCBs代表了对神经性厌食症治疗的潜在治疗点.
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