路比普和聚乙烯糖醇电解质洗液 (PEG-ELS) 与PEG-ELS用于慢性便秘时的肠道准备:一种随机对照试验
K Tangvoraphonkchai1,2,3, W Manasirisuk4, K Sawadpanich4
1Gastroenterology and Hepatology Unit, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand. Kawin_tang@hotmail.com.
Scientific reports
|September 27, 2023
概括
在患有慢性便秘的患者中,向聚乙烯糖醇电解质洗液 (PEG-ELS) 添加 lubiprostone 并没有改善肠道准备进行结肠镜检查. 这种组合在足够清洁或腺瘤检测方面没有比单独使用PEG-ELS显著的好处.
科学领域:
- 胃肠病学 胃肠病学
- 结肠直肠癌查 结肠直肠癌查
- 临床试验 临床试验
背景情况:
- 结肠镜对于检测结肠直肠癌至关重要,因为它依赖于有效的肠道准备.
- 慢性便秘对标准的肠道制备方法提出了挑战.
- 优化肠道清洁对于结肠镜疗效至关重要.
研究的目的:
- 为了比较分剂型聚乙烯糖醇电解质洗液 (PEG-ELS) 加上 lubiprostone 与单独使用 PEG-ELS 在便秘患者的肠道准备疗效.
- 为了评估 lubiprostone 对适当的肠道清洁率和结肠镜检查结果的影响.
主要方法:
- 进行了一项单中心,内镜师盲目的随机对照试验.
- 78名便秘患者接受了PEG-ELS与 lubiprostone或单独使用PEG-ELS.
- 通过太华肠道准备得分 (≤7) 评估了足够的肠道清洁.
主要成果:
- 在两组中,充分清理肠道的比率相似 (50%对52.9%,p=0.81).
- 在腺瘤检测率,不良事件或患者满意度方面没有发现显著差异.
- 在这个患者队列中,卢比普没有为肠道准备提供额外的益处.
结论:
- 在接受结肠镜检查的便秘患者中,皮质与分剂量PEG-ELS的组合不提高肠道准备.
- 对于慢性便秘患者,目前的肠道准备策略可能需要进一步优化.
- 需要进一步的研究,以确定有效的肠道制备方法,为这一群体.
相关概念视频
Drugs for Treatment of Constipation-Predominant IBS
197
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
197
Drugs for Treatment of Diarrhea-Predominant IBS
200
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
200
Drugs Affecting GI Tract Motility: Other Laxatives
256
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
256
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
234
Laxatives enhance bowel movements and alleviate constipation. They augment the stool's bulk, stimulate intestinal muscle contractions, draw water into the intestines, or soften the stool. There are five key types of laxatives: bulk laxatives, stimulant laxatives, osmotic laxatives, stool softeners, and lubricant laxatives.
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
234
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy
106
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
106
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
237
Diarrhea is characterized by the occurrence of frequent, watery bowel movements. Various factors can trigger diarrhea, including viral or bacterial infections, foodborne illnesses, side effects from certain medications, and underlying digestive disorders. If not adequately managed, diarrhea can lead to complications such as dehydration, electrolyte imbalances, and nutrient deficiencies. Severe diarrhea can lead to significant weight loss, malnutrition, and weakened immune function.
Adsorbents...
Adsorbents...
237


