初级侧面硬化症的语言缺陷:皮质缩,白质变性和大脑区域之间的功能断开
Ee Ling Tan1, Marlene Tahedl1, Jasmin Lope1
1Room 5.43, Computational Neuroimaging Group (CNG), School of Medicine, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.
Journal of neurology
|September 27, 2023
概括
主要侧面硬化症 (PLS) 不仅涉及运动神经元,还影响语言大脑区域和区域. 这项神经成像研究揭示了PLS患者语言网络的结构和功能变化.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 神经成像是一种神经成像.
背景情况:
- 主要侧面硬化症 (PLS) 传统上被视为一种纯粹的上部运动神经元疾病.
- 新出现的证据表明,PLS患者的认知缺陷,特别是在执行和语言领域.
研究的目的:
- 在PLS中研究与语言相关的大脑区域和网络的结构和功能完整性.
- 将PLS患者的神经成像发现与健康对照进行比较.
主要方法:
- 一个单中心前性神经成像研究,涉及40名PLS患者和111名健康对照.
- 进行全面的临床和遗传分析.
- 评估关键白质道的结构完整性 (例如,弧形,上纵) 和语言网络中的功能连接性.
主要成果:
- 维尼克和布罗卡区域的皮层厚度减少.
- 在与语言相关的区域,特别是左半球的结构变化 (减少分数异构,增加辐射扩散性).
- 补充运动区域和下额头椎之间功能连接减少,双边半球受影响.
结论:
- 在PLS中,疾病负担超越了运动区域,显著地涉及语言通道,网络和皮质区域.
- 语言障碍是PLS的一个显著方面,需要在患者管理中仔细考虑,因为与ALS相比,生存时间更长.
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