痛风与骨质疏松症和骨折风险之间的关联:一个元分析
Yani Liu1,2, Jihua Feng1, Pan Ji1
1Department of General Practice, The Second Affiliated Hospital of Guangxi Medical University, No. 166 Daxuedong Road, 530007, Nanning, China.
痛风与骨质疏松症的更高风险有关,但整体而言与骨折无关. 对于患有痛风的人来说,预防措施至关重要,以避免骨质疏松症并发症.
科学领域:
- 类风湿病学 类风湿病学
- 整形外科 整形外科 整形外科
- 流行病学 流行病学
背景情况:
- 痛风和骨质疏松症/骨折之间的联系尚不清楚.
- 这项研究评估了痛风与骨质疏松症和骨折风险的关联.
研究的目的:
- 综合评估关于痛风与骨质疏松症和骨折风险相关的文献.
- 为了确定痛风是否会增加骨质疏松症和骨折的风险.
主要方法:
- 在Medline,Embase和Cochrane图书馆进行了系统的文献搜索,直到2023年3月20日.
- 后分析从10项观察性研究 (1606,095名参与者) 中汇总了相对风险 (RR).
- 进行了敏感性分析和出版偏差测试 (Egger,Begg). 这项研究已注册在PROSPERO (CRD42022376822) 中.
主要成果:
- 痛风与骨质疏松症的风险增加显著相关 (RR = 1.25,95% CI 1.05-1.48).
- 痛风和骨折风险 (RR = 1.09,95% CI 0.99-1.19) 与高异质性之间没有发现总体关联.
- 亚组分析显示,痛风在中国人群中与骨折风险有关 (RR = 1.17,95% CI 1.14-1.21).
结论:
- 痛风增加了骨质疏松症的风险,但并没有增加整体骨折风险.
- 对于痛风患者来说,预防策略至关重要,以减轻骨质疏松症并发症.
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