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相关概念视频

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Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
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The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
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相关实验视频

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Measuring the Mechanical Properties of Living Cells Using Atomic Force Microscopy
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基于纳米机械的前列腺瘤分类使用原子力显微镜.

Jinshu Zeng1,2, Yan Zhang3, Renfeng Xu3

  • 1Department of Ultrasound Imaging, The First Affiliated Hospital, Fujian Medical University, Fuzhou, China.

The Prostate
|September 27, 2023
PubMed
概括

通过原子力显微镜 (AFM) 测量的纳米机械性质可以区分前列腺癌. 与正常组织相比,癌症前列腺组织和细胞的弹性降低,表明癌症分类的潜力.

关键词:
原子力显微镜的原子力显微镜.这是分类分类的分类.集群算法集群算法集群算法集群算法集群算法集群算法前列腺癌是前列腺癌.粘性弹性 粘性弹性

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科学领域:

  • 生物物理学的生物物理.
  • 癌症生物学 癌症生物学
  • 材料科学 材料科学 材料科学

背景情况:

  • 瘤细胞和微环境之间的机械稳态损失驱动转移.
  • 机械力量影响细胞增殖,分化,迁移和组织发育.

研究的目的:

  • 使用原子力显微镜 (AFM) 测量前列腺癌组织的纳米机械性质.
  • 研究生物力学特性与前列腺癌等级之间的关系.
  • 为了比较癌细胞和正常前列腺细胞的纳米机械性质.

主要方法:

  • 原子力显微镜 (AFM) 用于测量前列腺组织的生物力学特性.
  • 用K-means和模糊C-means集群来区分基于粘性弹性的细胞和非细胞组件.
  • 在体外对转移性 (PC-3) 和正常 (PZ-HPV-7) 前列腺细胞进行了AFM测量.

主要成果:

  • 的模量随着前列腺癌的进展而下降.
  • 癌症前列腺组织的弹性低于正常组织.
  • 转移的PC-3细胞比正常的PZ-HPV-7细胞更软,可能是由于癌细胞中活性细胞骨的增加.

结论:

  • 纳米机械特性可以有效地分类前列腺瘤.
  • 这些特性可以作为在细胞水平上识别和分类癌症的索引.