我们如何定义心力衰竭药物的高剂量和低剂量强度:范围审查
Min Ji Kwak1, Qian Wang2, Chukwuma Onyebeke3
1The University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston, TX, 77030, USA. min.ji.kwak@uth.tmc.edu.
BMC cardiovascular disorders
|September 27, 2023
概括
这项研究澄清了老年人心力衰竭药物的高剂量与低剂量. 大多数β抑制剂,ACE抑制剂和ARBs定义低剂量为<50%和高剂量为≥50%的目标.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 老年病的医生 老年病的医生
背景情况:
- 患有心力衰竭 (HF) 的老年人经常经历高剂量HF药物的不良药物事件.
- 目前的指导方针对低于目标剂量的剂量强度缺乏明确性,导致临床实践中的不确定性.
- 需要明确高强度和低强度HF药物的定义,以指导症状监测和治疗调整.
研究的目的:
- 进行范围审查,以确定最频繁使用的高剂量和低剂量的高炎药物的定义.
- 为了解决有关老年人高频率药物剂量强度的知识差距.
主要方法:
- 在PubMed,Embase,CINAHL和Cochrane图书馆进行了全面的文献搜索.
- 搜索术语旨在捕捉各种高频药物的强度.
- 审查了464篇文章,以确定不同HF药物类别的剂量强度的定义.
主要成果:
- 对40种药物确定了剂量强度的定义,对于大多数β抑制剂 (BBs),血管激素转化酶抑制剂 (ACEi) 和血管激素受体抑制剂 (ARBs) 达成了共识.
- 对于大多数BB,ACEi和ARB,低剂量被定义为指导目标剂量的<50%,高剂量为指导目标剂量的≥50%.
- 对于四种药物 (纳多洛尔,宾多洛尔,基拉扎普里尔和托塞米德) 的剂量强度定义,没有达成共识.
结论:
- 这次范围审查确定了40种高频率药物的经常使用的剂量强度定义,有助于临床实践.
- 这些发现有助于临床医生确定处方剂量是否高 (需要副作用监测) 或低 (需要剂量定位).
- 需要进一步的研究,以建立对剩余药物的共识定义.
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