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人类酒精微生物群小鼠对细菌性肺炎的敏感性增加

Kelly C Cunningham¹, Deandra R Smith², Daniel N Villageliú¹

¹Department of Internal Medicine-Pulmonary Division, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA.

|September 28, 2023

概括

慢性酒会改变肠道微生物群,增加对肺炎的易感性. 这项研究使用了人性化的小鼠模型,以显示酒精诱导的失生症会恶化感染和肺损伤.

科学领域:

微生物学和免疫学
胃肠病学胃肠病学
毒理学毒理学毒理学

背景情况:

慢性酒与胃肠道微生物群的改变有关,影响行为,生理和免疫力.
之前的研究在评估与酒精相关的肠道失调直接影响方面遇到了局限性.
了解酒精对肠道微生物群的影响对于解决与酒精有关的疾病至关重要.

研究的目的:

系统地评估由肠道失生症介导的慢性酒精滥用的免疫效应.
开发和利用一个人性化的酒精微生物群小鼠模型进行这项研究.

主要方法:

没有细菌的小鼠被人类便微生物群殖民,这些微生物群来自酒精使用障碍识别测试 (AUDIT) 成绩高低的个体.
便微生物群移植产生了人类与酒精相关的微生物群和人类控制微生物群F1后代.
在F1后代中对*Klebsiella pneumoniae*和*Streptococcus pneumoniae*肺炎的评估敏感性.

主要成果:

来自高AUDIT个体的微生物群的F1后代显示肺炎的死亡率增加.
肺部细菌负担和感染后的肺损伤在这些小鼠中明显高.
酒精诱导的肠道失调症加剧了对细菌性肺炎的易感性.

结论:

酒精诱导的肠道失调在慢性酒精滥用的免疫后果中起着至关重要的作用.
人性化的酒精微生物群小鼠模型有效地证明了失生症和增加感染易感性之间的联系.
调查与酒精有关的疾病需要考虑直接的酒精影响和酒精诱导的失生症,以制定有效的治疗策略.

关键词:

酒精酒精酒精酒精酒精酒精酒精肠肺轴肠肺轴肠肺轴肠肺轴东道主防御的防御方式这就是Klebsiella.微生物组是一个微生物组.肺炎是一种肺炎.这是一种链球菌.

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