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认知功能,神经递质变化和海马体微观结构变化在小鼠中,由西方饮食养引起的

Raly James Perez Custodio¹, Zaynab Hobloss¹, Maiju Myllys¹

¹Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund (IfADo), Ardeystrasse 67, 44139 Dortmund, Germany.

|September 28, 2023

概括

代谢功能障碍相关的性肝病 (MASLD) 诱导大脑变化,包括神经炎症和神经递质变化. 这种肝病会损害小鼠的认知功能和运动活动.

科学领域:

神经科学是一个神经科学.
肝病学肝病学是一种肝病学.
代谢障碍代谢障碍代谢障碍

背景情况:

代谢功能障碍相关的性肝病 (MASLD) 是一种普遍存在的慢性肝病.
新出现的证据将外周器官炎症,如MASLD,与中枢神经系统功能障碍联系起来.
马斯尔德对大脑组织学,认知和神经递质的具体影响仍然不完全理解.

研究的目的:

研究MASLD对大脑组织学,认知功能和神经递质特征的影响.
阐明在MASLD中肝-大脑轴中断背后的机制.

主要方法:

为了诱导MASLD,小鼠在48周内被食标准饮食 (SD) 或西方饮食 (WD).
综合行为测试评估了认知和运动功能.
尸检后的分析包括肝脏和大脑组织病理学,免疫组织化学和肝脑轴的生物化学分析.

主要成果:

用WD养的小鼠出现了代谢功能障碍相关的脂肪肝炎 (MASH) 的特征,肝损伤和炎症标志物升高.
大脑海马体显示血液毛细血管受损,星质症和微质症,这表明神经炎症.
用WD养的小鼠表现出注意力受损,运动活动,平衡,焦虑增加,以及大脑神经递质水平的改变.

结论:

在小鼠中诱导MASLD导致大脑细胞形态和神经递质表达的显著改变.
这些大脑变化与认知和行为功能受损有关.
这项研究强调了MASLD中肝脏健康和大脑功能之间的关键联系.

关键词:

马什 (MASH) 是一个非常重要的产品.太空神经分裂 (astrogliosis) 是一种肝-大脑轴的时间.微质化是一种微质化.神经炎症是一种神经炎症.

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