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基于生理学的细胞外囊的药物动力学建模

Prashant Kumar1, Darshan Mehta1, John J Bissler2

  • 1Division of Biochemical Toxicology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, AR 72079, USA.

Biology
|September 28, 2023
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模预测了细胞外囊泡 (EV) 的吸收,分布,新陈代谢和分泌. 这种方法优化了基于EV的药物输送系统,以提高临床应用中的治疗疗效和安全性.

关键词:
在 PBPK 建模中使用 PBPK 模型.药物输送是药物输送的过程.外基因组是外基因组的组成部分.细胞外囊泡中的细胞外囊泡.纳米颗粒是一种纳米粒子.药物动力学 药物动力学毒性的毒性 毒性的毒性

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