产生IFNγ的B细胞在感染介导的过敏抑制中起着调节作用
Sai Qiao1,2,3, Ying Peng1,2, Chunyan Zhang1,2
1Department of Immunology, Rady Max College of Medicine, University of Manitoba, Winnipeg, MB R3E 0T5, Canada.
Biology
|September 28, 2023
概括
甲状腺菌的肺部感染调节B细胞以抑制过敏呼吸道炎症. 这些B细胞产生IFNγ,这表明了过敏性疾病的新治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 过敏研究 研究过敏
背景情况:
- 卫生假说建议感染可以预防过敏,但机制尚不清楚.
- 之前的研究表明,克拉米迪亚菌 (Cm) 肺部感染通过树突细胞和T细胞抑制过敏炎症.
- 这项研究研究了B细胞在Cm介导的过敏调节中的作用.
研究的目的:
- 探索B细胞在感染了Chlamydia muridarum的小鼠中对过敏反应的作用.
- 为了确定受Cm感染的小鼠的B细胞是否可以抑制过敏气道炎症.
- 阐明Cm调节的B细胞影响过敏反应的机制.
主要方法:
- 从Cm-B感染小鼠 (Cm-B细胞) 和天真小鼠中采用B细胞转移到接受小鼠中.
- 使用卵胺 (OVA) 诱导过敏呼吸道炎症.
- 测量气道异敏性,粘液产生,Th2细胞因子,IgE/IgG1抗体和B细胞的IFNγ产生.
- 在收养转移期间使用单克隆抗体抑制IFNγ.
主要成果:
- 采用Cm-B细胞的转移,但不是天真的B细胞,显著抑制了OVA诱导的过敏气道异osinophilia和粘液过度产生.
- Cm-B细胞抑制了Th2细胞因子反应,并减少了总和OVA特异性IgE/IgG1抗体.
- 来自Cm感染小鼠的B细胞产生了更高水平的IFNγ.
- 阻断IFNγ消除了Cm-B细胞对过敏反应的抑制作用.
结论:
- 由Chlamydia muridarum肺部感染调节的B细胞在过敏呼吸道反应中起着调节作用.
- 这些B细胞的IFNγ产生对于抑制过敏性炎症至关重要.
- 这些发现为预防和治疗过敏疾病的潜在治疗点提供了新的见解.
更多相关视频
10:00High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
13.4K
07:07Evaluation of T Follicular Helper Cells and Germinal Center Response During Influenza A Virus Infection in Mice
Published on: June 27, 2020
5.3K
相关概念视频
B Cell Activation and Differentiation
1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
Immune Response Against Viral Pathogens
811
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
811
T Cell Types and Functions
1.1K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.1K
Antibody Structure
60.3K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
60.3K
NF-κB-dependent Signaling Pathway
7.5K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.5K
Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K
