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探索纵向肠道微生物群向早期儿童的亚托皮炎相关的代谢功能变化

Preecha Patumcharoenpol¹, Amornthep Kingkaw¹, Massalin Nakphaichit²

¹Interdisciplinary Graduate Program in Bioscience, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

|September 28, 2023

概括

儿童早期的亚托皮肤炎 (AD) 与特定的肠道细菌有关,即使整体肠道微生物群多样性没有变化. 这项研究强调了泰国儿童患有AD的关键细菌差异和代谢功能.

科学领域:

微生物学微生物学
免疫学免疫学免疫学
儿科健康儿科健康

背景情况:

亚托皮炎 (AD) 是一种常见的炎症性皮肤疾病.
生命早期肠道微生物组的改变与阿尔茨海默病有关.
有限的纵向研究存在于AD的肠道微生物组.

研究的目的:

在泰国患有AD的儿童中研究纵向肠道微生物组的分类学和代谢功能.
为了分析9至30个月大龄的肠道微生物变化.
建立一个监测过敏疾病中的微生物失衡的框架.

主要方法:

泰国儿童 (9-30个月) 肠道微生物组的纵向分析.
综合数据分析,以比较健康和AD群体.
微生物群落的分类学和功能概况.

主要成果:

健康和AD群体之间的肠道微生物群多样性没有显著差异.
在AD组中增加了SCFA产生细菌的丰富性 (例如,*Anaerostipes*, *Butyricicoccus*, *Ruminococcus*, *Lactobacillus*).
观察到与维生素生产和免疫反应相关的代谢变化 (例如,menaquinol,苏酸盐, (Kdo) 2-脂质A生物合成).

结论:

特定的肠道细菌和代谢功能与泰国儿童的阿尔茨海默病有关.
纵向微生物组分析为阿尔茨海默病发展提供了洞察力.
这项研究为了解小儿过敏疾病中的微生物作用提供了一个框架.

关键词:

亚托邦性皮肤炎的发生.早期的童年早期的童年纵向的肠道微生物组代谢功能代谢功能

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