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嗅觉功能障碍与阿尔茨海默病轨迹中的大脑粉样体沉积和认知功能有关
Sheng-Min Wang1, Dong Woo Kang2, Yoo Hyun Um3
1Department of Psychiatry, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Biomolecules
|September 28, 2023
概括
嗅觉功能障碍是阿尔茨海默病 (AD) 的常见症状,与大脑中的β-粉样蛋白 (Aβ) 积累有关. 这项研究表明,嗅觉障碍与AD进展中的认知衰退和Aβ沉积有关.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 老年学是一门学科.
背景情况:
- 嗅觉功能障碍是阿尔茨海默氏症 (AD) 早期症状之一.
- 嗅觉缺陷,大脑β-粉样蛋白 (Aβ) 沉积和AD进展中的认知状态之间的确切关系尚未完全理解.
研究的目的:
- 为了研究嗅觉功能,大脑Aβ沉积和神经心理资料之间的关联,在认知障碍的范围内的个人中,从没有认知障碍 (NCI) 到轻度认知障碍 (MCI) 和AD痴呆症.
- 为了确定Aβ沉积是否影响嗅觉功能,而不依赖于认知状态.
主要方法:
- 164名参与者通过简短的嗅觉识别测试 (B-SIT) 进行了嗅觉功能评估.
- 脑Aβ沉积量化使用[18F]-flutemetamol正子发射断层扫描 (PET) 成像.
- 进行了神经心理评估,以评估不同领域的认知功能.
主要成果:
- 在各组中观察到嗅觉功能的显著差异,在Aβ阳性MCI和AD痴呆症组中功能最低,在Aβ阴性NCI中最高.
- 嗅觉功能障碍在多个领域显示出与认知障碍的积极关联.
- 与没有Aβ的人相比,脑Aβ沉积的个体表现出较差的嗅觉功能,即使在类似的认知阶段.
- 嗅觉缺陷与全球和区域Aβ沉积有关.
结论:
- 嗅觉功能障碍与阿尔茨海默氏病连续体中的认知衰退和脑Aβ病理有关.
- 嗅觉缺陷可以作为一个有价值的生物标志物来跟踪AD的进展和了解疾病机制.
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