转化和强迫恐惧症症状预测了在被诊断为COVID-19的个人中IL-33和IL-28A水平
Kristina Stoyanova1, Drozdstoy Stoyanov1,2, Steliyan Petrov3,4
1Research Institute at Medical University of Plovdiv, Research Group "Translational and Computational Neuroscience", SRIPD, Medical University of Plovdiv, 4002 Plovdiv, Bulgaria.
Brain sciences
|September 28, 2023
概括
在COVID-19患者中,强迫恐惧症症状与IL-33水平之间存在关联. 焦虑抑郁症症状也影响了IL-28A和IL-33度,突显了冠状病毒感染中的精神神经免疫学联系.
科学领域:
- 心理神经免疫学 心理神经免疫学
- 传染病流行病学 传染病流行病学
- 临床心理学 临床心理学
背景情况:
- 由SARS-CoV-2引起的COVID-19流行病对全球健康产生了重大影响.
- 保加利亚的第一个流行病学浪潮是在2020年6月记录的.
- 了解COVID-19患者的心理和免疫相互作用至关重要.
研究的目的:
- 研究COVID-19幸存者的心理症状和特定细胞因子水平之间的关系.
- 探索焦虑抑郁症状与COVID-19感染后的INTERLEUKIN (IL) 水平之间的相关性.
主要方法:
- 评估了52名被诊断患有COVID-19后流行病学波的人群.
- 使用了焦虑抑郁度量 (ADS),包括各种症状维度 (BS,VS,CS,OPS,DS).
- 测量了IL-10,IL-28A和IL-33的血清水平,并与ADS得分相关联.
主要成果:
- 在强迫恐惧症症状 (OPS) 和IL-33水平之间观察到显著的相关性.
- 在所有被评估的患者中检测到升高的IL-10水平.
- 多重线性回归表明,转换症状 (CS) 和OPS解释了IL-33变异的28%,而所有ADS维度解释了24%.
- 所有ADS维度都解释了IL-28A水平的21%,OPS预测了较低的度.
结论:
- 这项研究揭示了心理神经免疫学因素和COVID-19的发病因子之间的显著相关性.
- 焦虑抑郁症状,特别是OPS和CS,与COVID-19患者的IL-33水平发生变化有关.
- 这些发现强调了在冠状病毒感染中心理痛苦和免疫反应之间的复杂相互作用.
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