肌酸补充剂对健康年轻成年人认知功能的剂量反应
Terence Moriarty1, Kelsey Bourbeau1, Katie Dorman1
1Department of Kinesiology & Athletic Training, University of Northern Iowa, Cedar Falls, IA 50614, USA.
Brain sciences
|September 28, 2023
概括
在年轻成年人中,补充肌酸并没有显著提高认知表现或改变前额叶皮层 (PFC) 激活. 这项研究发现,在6周内服用中等或高剂量的肌酸没有任何益处.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 认知心理学 认知心理学
背景情况:
- 肌酸是一种受欢迎的补充剂,通常与提高身体表现有关.
- 它对认知功能和大脑活动的影响仍然不太了解.
- 前额叶皮层 (PFC) 的激活对于复杂的认知任务至关重要.
研究的目的:
- 调查肌酸补充剂对认知表现的影响.
- 为了检查肌酸是否影响在认知任务期间前额叶皮层 (PFC) 的激活.
- 评估肌酸对认知和大脑活动的剂量依赖性影响.
主要方法:
- 30名参与者被随机分配到肌酸 (10g/天或20g/天) 或安慰剂组六周.
- 在补充前和后进行认知测试 (处理速度,记忆,注意力) 和fNIRS测量PFC氧血球 (O2Hb).
- 统计分析包括双向重复测量ANOVA和单向ANOVA的百分比变化.
主要成果:
- 无论剂量如何,肌酸补充剂在所有测试领域都没有显著改善认知表现.
- 一个不显著的趋势 (p=0.06) 表示在处理速度任务中,在每天10g的肌酸组中相对PFC O2Hb下降.
- 在肌酸组和安慰剂组之间没有观察到PFC激活的显著变化.
结论:
- 在年轻成年人中,服用中等或高剂量的肌酸补充剂6周并不能提高认知表现.
- 肌酸补充剂在认知任务期间没有显著改变PFC激活.
- 需要进一步的研究来探索潜在的微妙效应或特定条件,其中肌酸可能会影响认知.
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