咖啡因对ADHD儿童主要症状的影响:随机试验的系统审查和元分析
Giuliana Perrotte1, Marina Maria Gonzaga Moreira2, Amauri de Vargas Junior3
1Department of Neuroscience, Medical School, FMABC University Center, Santo André 09060-870, Brazil.
与安慰剂相比,咖啡因没有显著改善儿童注意力缺陷/多动障碍 (ADHD) 的症状. 这次系统性审查没有发现实质性证据支持咖啡因作为儿童患者ADHD症状的有效治疗方法.
科学领域:
- 儿科神经学 儿科神经学
- 心理药理学 心理药理学
- 基于证据的医学基于证据的医学.
背景情况:
- 注意缺陷/多动障碍 (ADHD) 通常用兴奋剂治疗,这可能会导致不良影响.
- 动物研究表明,咖啡因可以减轻ADHD的症状.
- 由于兴奋剂的副作用,研究咖啡因在儿科ADHD中的疗效至关重要.
研究的目的:
- 系统地审查和元分析咖啡因对儿童多动症症状的影响.
- 为了比较咖啡因与安慰剂在管理ADHD的整体症状,注意力不集中,过度活跃和冲动性.
- 综合了儿童多动症咖啡因随机对照试验 (RCT) 的研究结果.
主要方法:
- 系统性审查和RCT的元分析.
- 在PubMed,Embase和Cochrane数据库中搜索相关研究.
- 包括7个RCT (104名5至15岁的患者) 进行定性评估;4个RCT (76名患者) 进行元分析.
主要成果:
- 定性分析显示出混合的结果,大多数研究表明ADHD症状没有改善.
- 一项研究报告说,一般症状,注意力不集中和多动性有所改善.
- 定量元分析显示,咖啡因和安慰剂在整体多动症症状方面没有显著差异 (SMD -0.12;P=0.45).
结论:
- 目前的证据表明,咖啡因对治疗儿童ADHD症状的安慰剂没有显著的益处.
- 可能需要进一步的研究来探索潜在的特定效应或最佳剂量.
- 根据这项分析,咖啡因目前不被支持作为儿童多动症的主要治疗方法.
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