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微质炎症反应的降氧调节:通过Nrf2和NOX4精确控制NLRP3炎症体

Alejandra Palomino-Antolín1, Céline Decouty-Pérez1, Víctor Farré-Alins1

  • 1Unidad de Investigación, Hospital Santa Cristina, Instituto de Investigación Sanitaria Princesa (IIS-IP), 28006 Madrid, Spain.

Antioxidants (Basel, Switzerland)
|September 28, 2023
PubMed
概括

神经炎症涉及NLRP3炎症酶激活. 这项研究表明NADPH氧化酶4 (NOX4) 和核因子红色素2相关因子2 (Nrf2) 调节NLRP3,这表明NOX4抑制是神经退行性疾病的治疗策略.

关键词:
一个KO小鼠.在NLRP3炎症酶体中,NLRP3炎症在NOX4中,NOX4是Nrf2 没有任何问题.状细胞培养物炎症和免疫的作用神经退行性疾病的神经退行性疾病

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