甲乙醇:在癌症中失调的硫代谢的气味标记
Thilo Magnus Philipp1, Anne Sophie Scheller1, Niklas Krafczyk1
1Institute of Nutritional Sciences, Nutrigenomics Section, Friedrich Schiller University Jena, D-07743 Jena, Germany.
Antioxidants (Basel, Switzerland)
|September 28, 2023
概括
甲乙醇是一种挥发性硫化合物,在癌症中由于代谢变化和降解受损而增加. 这种化合物显示为早期,非侵入性癌症诊断的生物标志物具有前途.
科学领域:
- 生物化学 生物化学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 瘤细胞表现出代谢适应,包括改变硫代谢,导致挥发性硫化合物 (VSC) 的增加.
- 甲乙醇是一种主要的与癌症相关的VSC,与癌症患者的特征性气味有关.
- 甲乙醇的升高与结直肠癌 (CRC) 和其他癌症有关,表明其作为诊断生物标志物的潜力.
研究的目的:
- 研究甲乙醇作为非侵入性癌症诊断的生物标志物的作用.
- 探索导致癌症中甲乙醇水平升高的来源和代谢途径.
- 了解甲乙醇失调对癌症进展和临床结果的影响.
主要方法:
- 在生物样本中分析挥发性硫化合物 (VSCs).
- 对肠道微生物组合的研究,特别是产生甲乙醇的细菌,如Fusobacterium nucleatum.
- 评估结合蛋白1 (SELENBP1) 和甲基转移酶样蛋白7B (METTL7B) 的表达和活性.
- 评估非酶性甲乙醇生产途径,包括梅拉德反应.
主要成果:
- 甲乙醇被确定为与包括CRC在内的各种癌症相关的关键VSC.
- 在瘤中观察到SELENBP1,一种甲乙醇降解酶的下调,与预后不佳有关.
- 甲乙醇产量的增加可以通过酶 (例如,METTL7B) 和非酶途径发生,由高葡萄糖和甲氨酸水平加剧.
- 肠道细菌,如*Fusobacterium nucleatum*,有助于CRC患者的外源性甲乙醇暴露.
结论:
- 甲乙醇是癌症挥发性有机化合物 (VOC) 签名的重要贡献者.
- 不调节的硫代谢,受损的甲乙醇降解和增加的产量有助于其在癌症中的高水平.
- 甲乙醇作为早期癌症检测和诊断的非侵入性生物标志物具有前途.
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