旋转结构促进动脉保护壁剪切应力分布在一个动脉分叉模型
Nora C Wild1, Kartik V Bulusu1, Michael W Plesniak1,2
1Department of Mechanical and Aerospace Engineering, The George Washington University, 800 22nd Street NW, Science & Engineering Hall, Suite 3000, Washington, DC 20052, USA.
Bioengineering (Basel, Switzerland)
|September 28, 2023
概括
动脉中的流体动力学揭示了健康的螺旋结构通过增加有益的壁剪应力来防止动脉样硬化. 在预先处置的模型中,这种的恶化加快了斑块的形成.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 流体动力学 流体动力学
背景情况:
- 动脉疾病,包括动脉样硬化,是美国死亡的主要原因.
- 墙壁剪切应力与斑块形成有关,但潜在的流动结构仍然不明,特别是在高风险患者中.
- 开发了一种代表病理解剖学的"预先处置"动脉模型.
研究的目的:
- 研究复杂的流体结构及其与健康与预先处置的动脉分支中的壁切应力之间的关系.
- 了解血动力学变化如何促进动脉样硬化斑块的发展.
主要方法:
- 使用了计算流体动力学 (CFD) 模拟.
- 使用了来自健康人体的生理血流数据.
- 模拟了两个不同的动脉分叉模型:一个"健康"的模型和一个"预先处置"的病理模型.
主要成果:
- 在健康模型的内动脉鼻中发现了一个显著的头旋结构,增加了局部壁切削应力.
- 在预先处置的模型中,这种旋开始较早,寿命较短,二级流结构主导心脏周期的后半段.
- 预先配置的几何体表现出较弱的有利的轴向压力梯度峰值.
结论:
- 旋转结构与动脉壁剪切应力之间存在强烈的相关性.
- 一个完好无损的内动脉鼻螺旋旋通过增强局部墙壁剪切应力,起着保护性的生理作用.
- 这种有益的结构的破坏是动脉样硬化斑块形成的开始和进展的关键因素.
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