细颗粒物质扰乱了肉中的肺微生物群
Ying Zhou1, Bin Xu1, Linyi Wang1
1Institute of Animal Husbandry and Veterinary Science, Henan Academy of Agricultural Sciences, Zhengzhou 450002, China.
Animals : an open access journal from MDPI
|September 28, 2023
概括
细颗粒物 (PM2.5) 暴露会改变肉的肺部微生物群,并诱导炎症. 肺微生物群的这些变化可能会导致肺炎的发展.
科学领域:
- 环境健康 环境健康
- 微生物学 微生物学
- 兽医科学 兽医科学 兽医科学
背景情况:
- 细颗粒物 (PM2.5) 对动物和人类的呼吸系统健康产生负面影响.
- 人们越来越认识到肺微生物群在呼吸系统健康中的作用,但PM2.5的特定影响仍然不清楚,特别是在肉中.
研究的目的:
- 调查PM2.5暴露对 brojlers肺微生物群组成的影响.
- 评估PM2.5诱导的肺炎与肺微生物群的变化之间的关系.
主要方法:
- 48只肉被分为对照组和21天暴露于PM的组.
- 分析包括肺组织组织学,炎症生物标志物 (IL-6,TNFα,IFNγ,IL-10) 和肺微生物群测序.
主要成果:
- 暴露于PM2.5破坏了肺组织结构并诱导慢性炎症,以增加IL-6,TNFα,IFNγ和减少IL-10为标志.
- 观察到肺微生物群多样性的显著变化 (α和β).
- 在类层面上,PM2.5暴露减少了*Firmicutes*和增加了*Actinobacteria*和*Proteobacteria*,以及增加了*Rhodococcus*,*Achromobacter*,*Pseudomonas*和*Ochrobactrum*等属.
结论:
- 暴露于PM2.5会扰乱肉的肺微生物群,导致慢性肺炎.
- 改变的肺微生物组合与炎症标志物有关,可能在PM2.5诱导的肺病发展中发挥作用.
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