形状,酸性带炎和癌症:一个范围审查
Maxine Joly-Chevrier1, Alexa Gélinas1, Stephanie Ghazal2
1Faculty of Medicine, Université de Montréal, Montreal, QC H3T 1J4, Canada.
Cancers
|September 28, 2023
概括
这次审查表明,形病患者可能有较高的二次皮肤和胰腺癌的风险. 生性带炎 (EF) 数据有限,但有些病例可能是瘤性,癌症疗法可以诱导形状.
科学领域:
- 皮肤病学 皮肤病学
- 在瘤学瘤学.
- 类风湿病学 类风湿病学
背景情况:
- 莫菲亚是一种自身免疫性纤维性皮肤疾病.
- 乙酸性膜炎 (EF) 是一种严重的形状.
- 形态/EF与二次癌症之间的关联需要澄清.
研究的目的:
- 进行对Morphea/EF患者二次癌症风险的范围审查.
- 为了调查副瘤形态/EF.
- 评估癌症治疗的次要发展的形态/EF.
主要方法:
- 根据PRISMA-ScR指南进行范围审查.
- 搜索了MEDLINE,Embase和Cochrane数据库 (从开始到2022年9月).
- 包括201项研究:32项关于二次癌症,45项关于副瘤,125项关于治疗诱导的形态/EF.
主要成果:
- 有限的证据表明,在morphea,特别是泛型亚型中,皮肤和胰腺恶性瘤的风险增加.
- ~10%的EF病例可能是副瘤,与血液恶性瘤有关.
- 放射治疗诱导的形状异常是罕见的 (约0.2%);免疫治疗诱导的形状异常/EF正在出现,特别是在PD-1抑制剂.
结论:
- 莫菲亚患者可能面临二次恶性瘤的风险增加.
- 由于研究类型 (案例报告,系列,观察性研究) 的局限性,需要进一步的研究.
- 新出现的数据突出显示了与免疫疗法相关的morphea/EF.
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