在分散型大B细胞淋巴瘤患者的标准疗法周期期间,相对剂量强度的变化
Shin Lee1,2, Kei Fujita1,2, Tetsuji Morishita3,4
1Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan.
Cancers
|September 28, 2023
概括
在一线化疗期间保持平均相对剂量强度 (ARDI) 对扩散大B细胞淋巴瘤患者至关重要. 循环4-6的ARDI下降显著恶化了整体存活率,突出了早期治疗强度.
科学领域:
- 在瘤学瘤学.
- 血液学 血液学 血液学
- 临床药理学 临床药理学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是一种常见的非霍奇金淋巴瘤.
- 第一线化疗方案是标准的,但最佳剂量强度需要进一步研究.
- 平均相对剂量强度 (ARDI) 是化疗输送的度量,但其纵向影响在DLBCL中未得到充分研究.
研究的目的:
- 在DLBCL患者的第一线化疗中调查ARDI的轨迹.
- 评估ARDI模式与整体存活率 (OS) 之间的关联.
- 为了确定不利的ARDI变化的预测因素.
主要方法:
- 多中心,纵向,观察性回顾性研究.
- 对307名接受DLBCL第一线化疗的患者的分析.
- 使用多变量Cox危险建模和基于组的轨迹建模.
主要成果:
- 到第6周期的较高ARDI与预后益处有关.
- 两组患者的ARDI在4-6周期下降到50%以下,预后明显较差 (p=0.02).
- 老年人营养风险指数预测了不利的ARDI变化 (OR2.540,p=0.044).
结论:
- 保持ARDI,特别是在早期周期到第6周期,对于DLBCL患者的预后至关重要.
- 治疗中期显著减少ARDI与更糟糕的结果有关.
- 营养不良是与不利的ARDI轨迹和预后相关的重要因素.
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