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在垂体神经内分泌瘤/垂体腺瘤中PD-L1表达

Giulia Cossu¹, Stefano La Rosa^2,3, Jean Philippe Brouland³

¹Service of Neurosurgery, University Hospital of Lausanne, University of Lausanne, 1005 Lausanne, Switzerland.

|September 28, 2023

概括

编程细胞死亡配体1 (PD-L1) 表达与侵袭性垂体瘤亚型和p53表达有关. 需要进一步的研究来探索PD-L1.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

下垂体神经内分泌瘤 (PitNETs) 可以表现出侵略性行为,需要预测因素.
编程细胞死亡配体1 (PD-L1) 涉及侵袭性固体瘤,但其在PitNETs中的作用尚不清楚.

研究的目的:

为了研究PitNETs中的编程细胞死亡配体1 (PD-L1) 表达.
为了将PD-L1表达与放射性侵袭,病理发现和复发率相关联.

主要方法:

86个PitNET手术病例的回顾性分析.
使用瘤比例得分 (TPS) 的PD-L1表达的免疫组织化学评估.
评估与洞穴性鼻侵袭的关联,Trouillas的分类,p53,增殖标志物,荷尔蒙表达,瘤大小和复发.

主要成果:

在PD-L1表达显著高于在
这是一种增殖性增殖.
皮特网 (OR:5.78) 和与p53表达相关.
PD-L1和GH表达之间的正相关性 (OR:5.44);与FSH/LH表达的反相关性 (OR:0.27).
没有发现PD-L1表达与洞穴鼻入侵,瘤大小或复发之间存在关联.

结论:

PD-L1表达与繁殖的PitNET亚型和p53表达相关.
索马托罗夫瘤显示了更高的PD-L1表达.
需要进行更大规模的研究才能充分阐明PD-L1和PitNET攻击性之间的关系.

关键词:

在PD-L1中.这是一个PitNET,一个PitNET.生物行为是生物行为.发生性腺体的垂体瘤.免疫检查点抑制剂免疫检查点抑制剂免疫疗法免疫疗法下垂体腺瘤的前列腺瘤.预后预后预后索马托罗夫 pituitary 瘤在人体内缩.

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