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唾液和血代谢物作为HCC生物标志物的表征:试点研究

Courtney E Hershberger^1,2, Roma Raj^1,2,3, Arshiya Mariam^1,2

¹Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA.

|September 28, 2023

概括

唾液和血含有与肝细胞癌 (HCC) 相关的不同的代谢物. 这些生物标志物,特别是酸循环中的生物标志物,显示出改善HCC检测和理解其发展的前景.

科学领域:

代谢学代谢学代谢学
肝细胞癌研究肝细胞癌研究
生物标志物发现发现

背景情况:

肝细胞癌 (HCC) 的发病率不断上升,需要改进,敏感的查方法.
目前对HCC的诊断方法往往缺乏足够的灵敏度.
在可访问的生物流体中识别新生物标志物对于早期检测至关重要.

研究的目的:

识别与HCC相关的唾液和血中的明显和重叠的代谢物.
探索唾液和血代谢物的潜力,作为HCC检测的独立生物标志物.
调查代谢途径在HCC病变发生过程中的作用.

主要方法:

对来自HCC患者,肝硬化患者和健康对照者的唾液和血样本进行了非向性质谱学.
后勤回归分析确定了与HCC或肝硬化明显相关的代谢物.
途径丰富分析和皮尔森相关性用于分析代谢概况和样本间相关性.

主要成果:

六种唾液代谢物和十种血代谢物与HCC显著相关.
马龙酸显示了配对的唾液和血样本之间的相关性.
路径分析显示,HCC患者的唾液和血都对"酸循环"的放松调节.

结论:

唾液和血代谢物是检测HCC的潜在独立来源.
尽管单个代谢物相关性有限,但观察到"酸循环"途径的趋同.
"酸循环"途径与肝细胞癌的发病有关.

关键词:

生物标志物生物标志物癌症癌症癌症癌症癌症肝细胞癌是肝细胞癌.肝脏疾病是一种肝脏疾病.代谢生物组的代谢生物组

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