免疫疗法和肝移植:对基本和临床数据的叙述性审查
Charles-Henri Wassmer1, Sofia El Hajji1, Xenofon Papazarkadas1
1Division of Abdominal Surgery, Department of Surgery, Faculty of Medicine, Geneva University Hospitals, 1205 Geneva, Switzerland.
Cancers
|September 28, 2023
概括
免疫检查点抑制剂 (ICI) 对肝细胞癌 (HCC) 有好处,但对肝移植患者有风险. 建议在移植前进行洗期,以减轻急性排斥,避免移植后是理想的.
科学领域:
- 肝细胞癌 (HCC) 的管理
- 肝移植 免疫学 肝移植 免疫学
- 免疫治疗和移植的结果.
背景情况:
- 免疫检查点抑制剂 (ICI) 已经推进了HCC治疗.
- ICI可以改善某些HCC患者的移植候选人.
- 在移植环境中,在ICI治疗后报告了急性排斥事件.
研究的目的:
- 审查免疫检查点在HCC和肝移植中的影响.
- 分析关于ICI在肝移植周围使用的病例报告.
- 评估ICI治疗与肝移植有关的安全性和时间.
主要方法:
- 对案例报告和案例系列的文献综述.
- 在HCC中免疫检查点功能的分析.
- 检查ICI对肝移植结果的影响.
主要成果:
- 建议在ICI治疗和肝移植之间进行三个月的间隔.
- 建议在肝移植后避免ICI,特别是在早期.
- 目前的数据强调了ICI治疗与移植结合的挑战.
结论:
- 在肝移植候选人和接受者中,仔细考虑ICI的使用至关重要.
- 需要进一步的前性研究来建立最佳的协议.
- 与移植安全平衡HCC治疗的好处仍然是一个关键的挑战.
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