心脏剂量预测了食道状细胞癌中同时进行化学放射治疗的反应
Yu-Chieh Ho1, Yuan-Chun Lai2,3, Hsuan-Yu Lin4
1Department of Radiation Oncology, Changhua Christian Hospital, Changhua 500, Taiwan.
Cancers
|September 28, 2023
概括
预测宫食道癌的治疗反应对于生存至关重要. 关键因素包括心脏辐射剂量,血红蛋白,中性粒细胞-淋巴细胞比率和西斯剂量,影响最终化疗辐射的结果.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 医学物理 医学物理
背景情况:
- 绝对并发化疗 (CCRT) 是宫食道癌的标准.
- 预测治疗反应至关重要,因为它会影响生存.
- 对CCRT反应的验证预测标记是有限的.
研究的目的:
- 确定与宫食道癌患者治疗反应相关的临床变量和化疗辐射参数.
- 评估在接受CCRT的患者中预测整体生存 (OS) 的因素.
- 为了确定预测参数的最佳截止值.
主要方法:
- 来自86名完成CCRT的患者的临床,剂量计和实验室数据的回顾性分析.
- 对整体生存风险因素的考克斯回归分析.
- 后勤回归和ROC曲线分析 (尤登指数) 以确定与治疗反应相关的变量 (反应者与非反应者).
主要成果:
- 确定了50名响应者和36名非响应者,在OS方面存在显著差异.
- 多变量分析显示,心脏剂量-体积 (≥10 Gy),基线血红蛋白,CCRT期间最高的中性粒细胞-淋巴细胞比率,和累积的西斯普拉丁剂量与治疗反应有显著的关联.
- 最初的治疗反应与疾病的结果有显著的相关性.
结论:
- 心脏剂量-辐射量≥10 Gy,基线血红蛋白,中性粒细胞与淋巴细胞的比率和累积的西斯普拉丁剂量是宫食道癌治疗反应的显著预测因素.
- 这些因素可以帮助预测患者在最终的CCRT后的结果.
- 心脏辐射可能在治疗反应中发挥作用,需要进一步调查.
更多相关视频
相关概念视频
Imaging Studies for Cardiovascular System I:Echocardiography
359
Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
359
Imaging Studies for Cardiovascular System III: X-Ray
206
The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
206
Imaging Studies for Cardiovascular System V: CT
31
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
31
Dose-Response Relationship: Overview
3.2K
Agonists can bind with and activate receptors, resulting in the formation of drug-receptor complexes. Once formed, these complexes catalyze many biochemical processes at the cellular level and subsequently induce a pharmacologic response. The degree of response is directly proportional to the fraction of activated receptors, which in turn, depends on the concentration of the drug at the receptor site as well as the sensitivity of the receptor. An increase in the administered dose contributes to...
3.2K
Dose-Response Relationship: Potency and Efficacy
4.5K
The potency of a drug is the measure of its ability to produce a biological response and can be compared by looking at the half-maximum effective concentration or EC50 values of different drugs. A lower EC50 value indicates higher potency of the drug. In the dose–response curve of two antihypertensive drugs, candesartan and irbesartan, a significant difference is observed in their EC50 values. A lower EC50 value for candesartan indicates that it is more potent than irbesartan, as it...
4.5K
Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists
231
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
231


