在神经母细胞瘤中具有预后能力的c-MYC和MYCN的向基因在交上腺发育过程中表现出不同的表达

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Ye Yuan¹, Mohammad Alzrigat¹, Aida Rodriguez-Garcia¹

¹Department of Microbiology, Tumor and Cell Biology (MTC), Biomedicum, Karolinska Institutet, SE-171 65 Stockholm, Sweden.

Cancers

|September 28, 2023

概括

在MYC目标基因表达中的微妙差异可以将神经母细胞瘤 (NB) 患者分为风险组. 这种多基因评分预测了整体存活率和临床参数,提供了一种超出单基因表达的精细方法.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
发育生物学发展生物学

背景情况:

在人类癌症中,MYC家族转录因子 (c-MYC,MYCN,MYCL) 的放松调节是常见的.
在神经母细胞瘤 (NB) 中,MYCN放大和c-MYC过度表达发生在高风险病例中,但它们的发育作用尚不清楚.

研究的目的:

调查MYCN和c-MYC目标基因表达是否可以比个人基因表达更好地分层NB患者.
为NB患者分层开发一个多基因转录风险评分.

主要方法:

从498名NB患者 (SEQC队列) 的转录组综合分析.
使用定义的c-MYC和MYCN目标基因建模多基因转录风险评分.

主要成果:

定义的c-MYC和MYCN目标集显示出显著的预后价值,通过整体存活率对NB患者进行分层.
高风险特征得分与不利的临床参数相关:风险增加,更高的INSS阶段,MYCN放大和疾病进展.
预后标基因在c-MYC和MYCN之间有所不同,在发育中的交上腺细胞 (交细胞与细胞) 中具有不同的表达模式.

结论:

基于MYC目标基因的多基因转录风险评分有效地分层NB患者.
这种方法细化了风险分层,超出了单个MYC基因表达的范围,有助于理解NB的病原性.
在交感上腺发育中,c-MYC和MYCN点的不同作用可能会影响NB的发病和进展.

关键词:

这就是MYCNCN.c-MYCC 这是一个很好的例子.基因签名基因签名基因签名神经母细胞瘤的神经母细胞瘤预后预后预后同情性上腺发育.

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