内分泌器官和受内分泌系统调节的目标组织的三维模型
Edlira Luca1, Kathrin Zitzmann2, Stefan Bornstein1,3
1Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8091 Zurich, Switzerland.
Cancers
|September 28, 2023
概括
标准细胞培养不能完全代表瘤,阻碍了癌症治疗的发展. 有机体和球体为临床前癌症研究和个性化医学提供了更好的3D模型.
科学领域:
- 在瘤学瘤学.
- 3D细胞培养模型
- 癌症研究 癌症研究
背景情况:
- 单层培养中的不朽细胞系提供可再生性,但与体内瘤不同.
- 细胞系的同质性和二维性质限制了治疗的发展和可翻译性.
- 目前的模型不能充分反映固体瘤的复杂结构和异质性.
研究的目的:
- 审查生成3D有机体和球体模型的进展.
- 探索从内分泌组织中创造活生物库的方法.
- 讨论个性化癌症医学中的应用.
主要方法:
- 对产生有机体和球体的既定方法的审查.
- 专注于内分泌组织和相关的目标器官.
- 将3D模型与生物银行集成,以实现个性化的方法.
主要成果:
- 有机体和球体模仿瘤异质性和3D架构.
- 这些3D模型更好地概括了体内瘤特征.
- 进步促进了个性化医疗战略的发展.
结论:
- 三维有机体和球体模型对于克服传统细胞系的局限性至关重要.
- 这些模型增强了癌症治疗的临床前评估.
- 从内分泌组织开发生物库支持个性化治疗策略.
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