神经精神病莱姆病和迷你神经刺激
Nicholas Biniaz-Harris1, Mara Kuvaldina1,2, Brian A Fallon1,2,3
1Lyme & Tick-Borne Diseases Research Center at Columbia University Irving Medical Center, 1051 Riverside Drive, New York, NY 10032, USA.
Antibiotics (Basel, Switzerland)
|September 28, 2023
概括
治疗后莱姆病综合征 (PTLS) 影响一些患者尽管抗生素治疗. 新的疗法,如迷走神经刺激 (VNS),正在探索持续的莱姆病症状.
科学领域:
- 神经科学是一个神经科学.
- 传染性疾病 传染性疾病
- 医疗技术 医疗技术 医学技术
背景情况:
- 莱姆病是由*Borrelia burgdorferi*引起的,是美国最常见的传播疾病.
- 虽然急性莱姆病是可以治疗的,10-30%的患者经历了治疗后的症状,5-10%的患者患上了带有疼痛,疲劳或认知问题的PTLDS.
- 持续的莱姆病症状的确切原因是未知的,但理论包括正在进行的感染,神经变化或免疫系统功能障碍.
研究的目的:
- 审查莱姆病,重点关注神经精神病和持久症状.
- 探索莱姆病后持续症状的新型治疗方案.
- 为了评估迷走神经刺激 (VNS) 对PTLDS的潜力.
主要方法:
- 这是一个叙事综述,综合了现有的莱姆病和VNS的研究.
- 这篇评论讨论了莱姆病的当前治疗方法.
- 它特别研究了穿皮VNS (taVNS) 作为一种潜在的治疗方法.
主要成果:
- 莱姆病后持续的症状,包括PTLDS,需要新的治疗策略.
- 神经刺激 (VNS) 是FDA批准的用于其他疾病的神经调节技术.
- 穿皮VNS (taVNS) 是最小的侵入性和一般耐受良好.
结论:
- 对于在莱姆病后出现持续症状的患者,需要新的治疗方法.
- 通过皮肤进行的耳膜VNS显示出作为PTLDS的潜在治疗方法的希望.
- 需要进一步的严格研究来确认taVNS对慢性莱姆病综合征的疗效.
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