COVID-19如何影响巴西的抗菌素消费和细菌耐药性概况?
Natália Cassago Marcos Massarine1, Gleyce Hellen de Almeida de Souza1, Isadora Batista Nunes1
1Health Sciences Research Laboratory, Universidade Federal da Grande Dourados, Dourados 79825-070, MS, Brazil.
在COVID-19期间,巴西的抗生素滥用急剧增加,医院抗菌剂消费量增加了26%,耐药性率增加了26%. 这一趋势,特别是阿齐思罗米,与COVID-19发病率相关,突出显示了日益增长的公共卫生威胁.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 不分青红白地使用抗生素会导致抗菌素耐药性.
- 了解处方模式和耐药性对于公共卫生至关重要.
研究的目的:
- 评估巴西 (2018-2021) 的抗生素处方模式.
- 分析中央线路相关血流感染 (CLABSI) 率和耐药性概况.
- 与抗菌素消费与耐药性和COVID-19发病率相关联.
主要方法:
- 评估了国家抗微生物消费数据 (医院和社区).
- 分析了CLABSI发病率和耐药性数据.
- 利用皮尔森的相关性,将阿齐思罗米使用与COVID-19联系起来.
主要成果:
- 在2021年,医院的抗菌药物消费量增加了26%;polymyxin B增加了204%.
- 报告了244,266例CLABSI病例 (临床治疗率为7.9%).
- 在Pseudomonas aeruginosa (1400%) 和Klebsiella pneumoniae (514%) 中存在高多素B耐药性. 阿齐思罗米是最常用的社区抗生素 (24%),与COVID-19相关 (r=0.71).
结论:
- 在COVID-19大流行期间,抗菌药物的消费量增加.
- 滥用抗微生物药物有助于扩大抗微生物药物耐药性.
- 需要紧急干预,以制抗生素的滥用和打击耐药性.
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