抗生素耐药性:道尽头有没有"光"?
Leon G Leanse1,2, Sanjay Marasini3, Carolina Dos Anjos2
1Health and Sports Sciences Hub, University of Gibraltar, Europa Point Campus, Gibraltar GX11 1AA, Gibraltar.
Antibiotics (Basel, Switzerland)
|September 28, 2023
概括
抗菌素耐药性 (AMR) 是一个日益增长的全球威胁. 基于光的疗法,如抗微生物光动力学疗法 (aPDT),在对抗耐药性感染的过程中具有极小的耐药性发展.
科学领域:
- 微生物学与传染病的研究
- 生物医学工程 生物医学工程
- 照相医疗 (photomedicine) 是一种医学.
背景情况:
- 抗菌素耐药性 (AMR) 的上升构成了全球严重的健康威胁,多药耐药生物体 (MDROs) 进一步加剧了这一威胁.
- COVID-19 流行病加剧了MDRO感染的挑战,使全球的医疗保健系统受到压力.
- 基于光的治疗方法在治疗癌症和传染病方面有着悠久的研究历史.
研究的目的:
- 阐明抗菌素耐药性 (AMR) 背后的多种机制,包括内在,表型和获得的耐药性.
- 审查各种基于光的治疗方式,包括抗微生物光动力疗法 (aPDT),抗微生物蓝光 (aBL) 和紫外线 (UV) 光.
- 评估基于光的疗法的临床可行性和整合要求,作为传统抗菌素的替代品或辅助剂.
主要方法:
- 关于抗微生物药物耐药机制的综合文献综述.
- 对抗微生物应用的基于光疗法 (aPDT,aBL,紫外线) 的现有研究进行分析.
- 对基于光的干预措施的临床翻译挑战和要求的评估.
主要成果:
- 基于光的方法证明了有效杀死病原体,无论AMR状态如何.
- 与传统抗生素相比,这些疗法与耐药性发展的低倾向有关.
- 各种基于光的方法提供了作为对抗耐药微生物的独立或补充治疗的潜力.
结论:
- 基于光的疗法代表了一种有前途的策略,以应对不断升级的抗菌素耐药性危机.
- 需要进一步的研究和临床评估,以促进aPDT,aBL和UV光的整合到标准医疗实践中.
- 这些模式提供了一条可行的途径,以克服由多抗药生物体 (MDROs) 引起的感染.
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