在连续四次SARS-CoV-2流行浪潮期间,重症监护室的血液感染
Giacomo Pozza1,2, Giacomo Casalini1,2, Cosmin Lucian Ciubotariu1,2
1III Division of Infectious Diseases, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, 20157 Milan, Italy.
Antibiotics (Basel, Switzerland)
|September 28, 2023
概括
严重病情的COVID-19患者的血流感染 (BSI) 在流行病期间保持稳定. 然而,随着时间的推移,Enterococcus物种引起的感染显著减少.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 流行病学 流行病学
背景情况:
- 患有COVID-19的重症患者面临血液感染 (BSI) 的风险增加.
- 了解重症监护室 (ICU) 中的BSI的发病率和趋势对于患者管理至关重要.
研究的目的:
- 评估进入ICU的重症COVID-19患者血流感染 (BSI) 的发生率和趋势.
- 确定导致BSI的病因因子,并分析它们在不同流行时期的流行率.
主要方法:
- 一项回顾性,观察性,单中心研究对404名入住ICU的重症COVID-19患者进行了观察.
- 在ICU入院后48小时发生的BSI的数据在四个连续时期内收集.
- 估计BSI的发病率是使用Poisson分布来估计的,正常化为1000个患者日.
主要成果:
- 总体粗略的BSI发生率为每1000个患者日87次,在流行时期没有显著差异 (p = 0.357).
- 阳性细菌是导致BSI的主要原因,占发病率的74.6%.
- 由Enterococcus spp.引起的BSI显著逐渐减少. 观察到,从W1的57.4%到W4的32.7% (p = 0.004).
结论:
- 在重症COVID-19患者中,血流感染的发生率在整个研究期间保持稳定.
- 虽然整体BSI发病率保持不变,但Enterococcus spp.显著减少. 作为一种致病剂.
- 尽管下降了,Enterococcus spp. 尽管下降了,Enterococcus spp. 在晚些时候的流行病阶段,仍占有大量的BSI.
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