相关实验视频

Updated: Jul 15, 2025

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

在患有高级软组织肉瘤的狗中使用oclacitinib和myxoma病毒治疗

Laura V Ashton¹, Kristen M Weishaar², Bernard Séguin³

¹Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO 80523, USA.

|September 28, 2023

概括

结合型病毒疗法 (OV) 和免疫疗法,在治疗犬类软组织肉瘤 (STS) 方面表现有前途. 虽然单独使用OV可以减少瘤的再生,但在本研究中,组合疗法没有产生进一步的益处.

科学领域:

兽医瘤学兽医瘤学
免疫治疗是一种免疫疗法.
瘤解毒病毒疗法病毒疗法

背景情况:

狗的软组织肉瘤 (STS) 与人类的狂犬病肉瘤有相似之处,这使得狗模型对癌症治疗研究具有价值.
将瘤性病毒疗法 (OV) 与免疫疗法相结合,有可能改善狗和人类患者的癌症治疗结果.

研究的目的:

调查OV与免疫疗法结合治疗犬肉软组织肉瘤 (STS) 的疗效.
评估I型干扰素 (IFN) 在限制瘤病毒 (MYXV) 在狗癌细胞中复制中的作用,并探索减轻这种影响的策略.

主要方法:

狗癌细胞感染了myxoma病毒 (MYXVs),以分析基因转录和细胞因子度.
在STS瘤外科切除之前,用JAK1抑制剂oclacitinib给狗,以减少I型IFN的产生.
手术后,在手术部位注射了为serp2删除的MYXV (MYXV∆SERP2),以向剩余的微观瘤细胞.

主要成果:

瘤病毒 (MYXV) 在狗癌细胞中的复制被发现受到I型干扰素 (IFN) 的限制,类似于小鼠和人类细胞.
与历史对照相比,在接受OV治疗的狗中,瘤的再生增长减少.
组合治疗,包括免疫疗法和OV,与单独的OV相比,没有进一步抑制瘤再生.

结论:

单独的瘤解毒性病毒疗法 (OV) 显示在减少犬类软组织肉瘤 (STS) 瘤再生增长方面具有积极影响.
在这项研究中,OV与免疫治疗的结合,特别是使用oclacitinib来抑制I型IFN,并没有改善治疗结果.
需要进一步的研究,以优化包括OV和免疫治疗在内的犬类和人类癌症治疗的组合策略.

关键词:

癌症癌症癌症癌症癌症细胞因子细胞因子这些狗狗狗狗狗狗狗.奥克拉西提尼布 (oclacitinib) 是一种药.科性病毒病毒.

更多相关视频

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats

Published on: October 24, 2016

相关概念视频

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...