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Updated: Jul 15, 2025

A 3D Spheroid Model as a More Physiological System for Cancer-Associated Fibroblasts Differentiation and Invasion In Vitro Studies
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球状体是一个相关的模型来解决纤维化在状体研究?

Zélie Dirand1, Marion Tissot1, Brice Chatelain2

  • 1Université de Franche-Comté, Sciences Médicales et Pharmaceutiques, EFS, INSERM, UMR RIGHT, 25000 Besançon, France.

Biomedicines
|September 28, 2023
PubMed
概括

在3D球形中培养的状纤维细胞惊人地显示出纤维基因活性降低. 这表明球体对研究纤维细胞失活的效果要好,而不是 keloid 纤维生成.

关键词:
这是一个ECM,ECM是ECM.在TGF-β1中.纤维化 纤维化keloid 纤维细胞 纤维细胞球形形状的球形状α-SMAMA 的使用.

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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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