相关实验视频
Updated: Jul 15, 2025

07:32
Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
4.1K
肠道失调症:对于中风预防和治疗的新途径
Shin Young Park1, Sang Pyung Lee2, Dongin Kim3
1Department of Clinical Laboratory Science, Cheju Halla University, 38 Halladaehak-ro, Jeju-si 63092, Republic of Korea.
Biomedicines
|September 28, 2023
概括
脑卒中患者表现出肠道微生物群失调,细菌组成和功能发生变化. 这表明了与营养不良的潜在联系,并为治疗干预提供了新的途径.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 胃肠病学 胃肠病学
背景情况:
- 脑卒中是导致死亡和残疾的主要原因,治疗选择有限.
- 研究正在扩大以调查中风患者的外围变化,包括肠道微生物组.
- 肠道微生物组在宿主健康和疾病中起着至关重要的作用.
研究的目的:
- 与健康对照人群相比,研究中风患者的肠道微生物群组成和功能.
- 为了确定与中风相关的特定微生物和功能变化.
- 探索这些变化对营养不良和治疗策略的潜在影响.
主要方法:
- 从25名中风患者和26名健康对照组中收集了便样本.
- 16S rRNA基因的V3-V4区域使用Illumina MiSeq.进行了测序.
- PICRUSt2被用于元基因组功能预测.
主要成果:
- 脑卒中患者表现出显著的分类失调,增加了Parabacteroides和Escherichia_Shigella,并且减少了Prevotella和Fecalibacterium.
- 观察到功能性失生症,其特征是转移酶和/运输系统蛋白质的水平较高,RNA聚合酶sigma-70因子和甲基接受化学反应蛋白质的水平较低.
- 这些功能性变化表明中风患者的潜在营养不良.
结论:
- 肠道微生物群失生症在中风患者中很明显,影响了分类学和功能概况.
- 肠道微生物组的变化可能与中风中的营养不良有关.
- 针对肠道微生物群的营养干预可能会改善中风预后,减少残疾和死亡率.
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
348
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
348
Irritable Bowel Syndrome I: Introduction
304
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
304
Inflammatory Bowel Disease IV: Pharmacological Management
145
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
145
Drugs Affecting GI Tract Motility: Antimicrobials as Antidiarrheal Agents
143
Acute diarrhea, a common gastrointestinal disturbance, is characterized by the rapid evacuation of fluid stools, leading to an excessive weight in fluid. This condition typically arises from disorders affecting intestinal water and electrolyte transport. It can be triggered by an increased osmotic load within the intestine, excessive secretion of electrolytes and water, mucosal exudation of protein and fluid, or altered intestinal motility. The primary risks of acute diarrhea are dehydration...
143
Chronic Bowel Disorders: Introduction
474
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
474
What is Monogastric Digestion?
71.4K
The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.
71.4K

