结肠直肠癌中的长非编码RNA:导航免疫,细胞间通信和治疗潜力的交叉点
Nikolay K Shakhpazyan1, Liudmila M Mikhaleva1, Arcady L Bedzhanyan2
1Avtsyn Research Institute of Human Morphology, Petrovsky National Research Center of Surgery, 119435 Moscow, Russia.
Biomedicines
|September 28, 2023
概括
长非编码RNAs (lncRNAs) 是结直肠癌 (CRC) 进展,免疫逃避和治疗反应的关键参与者. 了解lncRNAs为CRC生物标志物和治疗提供了新的途径.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 长非编码RNAs (lncRNAs) 越来越多地被认为对癌症的发展和进展起作用.
- 瘤微环境显著影响结肠直肠癌 (CRC) 发病,免疫反应和治疗结果.
- 了解CRC微环境中的复杂相互作用对于开发有效的治疗方法至关重要.
研究的目的:
- 综合审查 lncRNAs 在结直肠癌 (CRC) 微环境中的多方面的作用.
- 探索lncRNAs在CRC病变发生,免疫逃避,炎症和治疗策略中的参与.
- 突出 lncRNAs 作为生物标记物和CRC中的治疗点的潜力.
主要方法:
- 对调查结直肠癌中 lncRNAs 的研究进行文献综述.
- 对lncRNA与CRC共识分子亚型 (CMS) 相互作用的分析.
- 检查lncRNA参与瘤肌瘤,免疫力和炎症的情况.
- 通过细胞外囊泡 (外体) 检查 lncRNA 运输.
- 探索 lncRNA 与细胞通信中的其他非编码RNA (微RNA,圆形RNA) 的相互作用.
主要成果:
- lncRNAs在CRC病变发生,免疫规避和治疗反应方面具有重要影响.
- lncRNA与CRC共识分子亚型 (CMSs) 相互作用,影响瘤层,影响免疫力和炎症.
- 细胞外囊泡,特别是外体,被确定为IncRNA传输的关键媒介.
- lncRNAs与microRNAs和循环RNAs一起,在CRC微环境中的细胞间通信中发挥关键作用.
结论:
- lncRNAs是CRC微环境中的关键调节者,影响免疫,通信和治疗反应.
- 针对 lncRNAs 提出了一个有前途的战略,用于开发新生物标志物和治疗CRC的治疗干预措施.
- 操纵lncRNAs有可能增强抗瘤免疫力并改善CRC治疗结果.
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