肥胖相关的脏疾病:当前的理解和未来的前景
Frederik F Kreiner1, Philip Andreas Schytz1, Hiddo J L Heerspink2
1Novo Nordisk A/S, DK-2860 Søborg, Denmark.
Biomedicines
|September 28, 2023
概括
肥胖是慢性病 (CKD) 的一个主要风险因素. 需要新的治疗方法来解决与肥胖相关的病 (OKD),考虑到目前的选择在体重管理和长期疗效方面存在局限性.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
背景情况:
- 肥胖是一种重要的慢性疾病,也是慢性病 (CKD) 发展和恶化的主要危险因素.
- 预计CKD的患病率将上升,部分原因是肥胖率的增加.
- 肥胖相关病 (OKD) 是一种复杂的疾病,涉及肥胖,CKD和糖尿病和高血压等心脏代谢因素的相互作用.
研究的目的:
- 突出研究肥胖相关脏疾病 (OKD) 复杂病理生理学的迫切需要.
- 评估当前针对肥胖和CKD的治疗策略,并注意到它们的个体向和局限性.
- 探索新兴药理学干预的潜力,如葡萄糖类-1 (GLP-1) 受体激活剂,用于管理OKD.
主要方法:
- 关于肥胖,CKD和OKD的当前文献的综述.
- 分析现有的治疗方法,包括非药物 (生活方式,手术) 和药物干预措施.
- 评估特定药物类别 (SGLT2抑制剂,芬,GLP-1激动剂) 对体重和功能的影响.
主要成果:
- 目前针对肥胖和慢性脏病的治疗方法通常单独针对每一种疾病.
- 非药物干预显示了可变的疗效和长期可持续性.
- 诸如SGLT2抑制剂和finerenone之类的药理学药物提供脏保护,但体重减轻最小;GLP-1激动剂在减肥和潜在的脏益处方面表现有前途.
结论:
- 对OKD的相互连接机制进行进一步调查是非常必要的.
- 开发综合治疗策略对于管理这种日益复杂的疾病至关重要.
- 同时针对肥胖和脏疾病对于改善患者的治疗结果至关重要.
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